Why test IgG for food sensitivity?

There is a growing body of evidence to support the clinical benefits of eliminating IgG-reactive foods from the diet. IgG food sensitivities have been implicated in migraine headaches. Bloating and indigestion are also common food sensitivity reactions, as is fatigue. Because IgG food reactions take hours or days to develop, this makes it difficult to determine which food is responsible for the reaction without doing testing. Several research studies suggest there are benefits to performing food elimination diets based on what foods cause an IgG food reaction. We've included the studies below. 

1. Alpay, K, et al. Diet restriction in migraine, based on IgG against foods: A clinical double-blind, randomised, cross-over trial.  Sage Journals. Volume: 30 issue: 7, page(s): 829-837. Retrieved from: http://journals.sagepub.com/doi/abs/10.1177/0333102410361404

2. Arroyave Hernandez CM, et al. Food allergy mediated by IgG antibodies associated with migraine in adults. Rev Alerg Mex.2007 Sep-Oct;54(5):162-8. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/18693538

3. Atkinson, W., T. A. Sheldon, et al. (2004). “Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial.”   Gut 53(10): 1459-1464. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/15361495

4. Aydiniar, E, et al. IgG-based elimination diet in migraine plus irritable bowel syndrome.  Headache. 2013 Mar;53(3):514-25. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/2321623

5. Bentz S, et. al. Clinical relevance of IgG antibodies against food antigens in Crohn's disease: a double-blind cross-over diet intervention study. Digestion 2010; 81: 252–264. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/20130407

6. Cai, C, et al. Serologic Investigation of Food Specific Immunoglobulin G Antibodies in Patients with Inflammatory Bowel Diseases. PLOS November 2014: Volume 9; Issue 11, e112154. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/25393003

7. Carini, C., et al. Immune complexes in food-induced arthralgia.  Ann Allergy.1987 Dec;59(6):422-8. Retrieved from:https://www.ncbi.nlm.nih.gov/pubmed/3425981

8. Coucke, F. Food intolerance in patients with manifest autoimmunity. Observational study. Autoimmun Rev. 2018 Nov;17(11):1078-1080. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/30213697

9. Dixon, HS. Treatment of delayed food allergy based on specific immunoglobulin G RAST testing.   Otolaryngol Head Neck Surg.2000;123:48-54. https://www.ncbi.nlm.nih.gov/m/pubmed/10889481/

10. Drisko, J., B. Bischoff, et al. (2006). “Treating irritable bowel syndrome with a food elimination diet followed by food challenge and probiotics.”   Journal of the American College of Nutrition 25(6): 514-522. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/17229899

11. Hernandez, A., et. Al. Food allergy mediated by IgG antibodies associated with migraine in adults. Rev Alerg Mex. 2007 Sep-Oct;54(5):162-8. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/18693538

12. Hodsdon, W. ND and Heather Zwickey, PhD, (2010). Reproducibility and Reliability of Two Food Allergy Testing Methods. Natural Medicine Journal 2(3), March, 2010. Retrieved from: https://www.researchgate.net/publication/242659400_NMJ_Original_Research_Reproducibility_and_Reliability_of_Two_Food_Allergy_Testing_Methods.

13. Jian, L. et aql. Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study. Inflamm Bowel Dis. 2018 May 16. doi: 10.1093/ibd/izy110. [Epub ahead of print]. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/29788288
14. Karakula-Juchnowicz, H., et al. The Food-Specific Serum IgG Reactivity in Major Depressive Disorder Patients, Irritable Bowel Syndrome Patients and Healthy Controls. Nutrients 2018, 10(5), 548. Retrieved from:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986428/
15. Shakoor Z, AlFaifi A, AlAmro B, AlTawil LN, AlOhaly RY. Prevalence of IgG-mediated food intolerance among patients with allergic symptoms. Ann Saudi Med. 2016;36(6):386-390. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/27920409

16. Xiao, N., et al. Food-specific IgGs Are Highly Increased in the Sera of Patients with Inflammatory Bowel Disease and Are Clinically Relevant to the Pathogenesis. Intern Med. 2018 Oct 1;57(19):2787-2798. doi: 10.2169/internalmedicine.9377-17. Epub 2018 May 18. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207831/

17. Yang, C. M. and Y. Q. Li (2007). “[The therapeutic effects of eliminating allergic foods according to food-specific IgG antibodies in irritable bowel syndrome].” Zhonghua nei ke za zhi [Chinese journal of internal medicine] 46(8): 641-643. Retrieved from:  https://www.ncbi.nlm.nih.gov/pubmed/17967233

18. Zar, S., et al. Food-specific IgG4 antibody-guided exclusion diet improves symptoms and rectal compliance in irritable bowel syndrome. Scand J Gastroenterol. 2005 Jul;40(7):800-7. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/16109655

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