Why test IgG for food sensitivity?

There are multiple studies that suggest that removal of high IgG reactivity foods corresponds to reduced symptoms such as gastrointestinal issues, skin conditions, or migraines, as well as other symptoms people experience as a result of consuming certain foods.

Some studies that are against IgG testing are actually focused on whether IgG testing helps predict or diagnose food allergies, which isn’t how consumers should use our Food Sensitivity test. The Food Sensitivity test is not an allergy test, and we state that clearly on our site.

Here is a list of peer-reviewed studies on IgG food testing and elimination diets

  1. Neuendorf R, et.al. Impact of Food Immunoglobulin G-Based Elimination Diet on Subsequent Food Immunoglobulin G and Quality of Life in Overweight/Obese Adults. J Altern Complement Med. 2019 Feb;25(2):241-248. Retrieved from: https://www.liebertpub.com/doi/full/10.1089/acm.2018.0310?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubme
  2.  Werlang ME, Palmer WC, Lacy BE. Irritable Bowel Syndrome and Dietary Interventions. Gastroenterol Hepatol (N Y). 2019;15(1):16–26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423692/
  3. Coucke F. Food intolerance in patients with manifest autoimmunity. Observational study. Autoimmun Rev. 2018 Nov;17(11):1078-1080. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/30213697
  4. Jian L. et aql. Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study. Inflamm Bowel Dis. 2018 May 16. doi: 10.1093/ibd/izy110. [Epub ahead of print]. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/29788288
  5. Karakula-Juchnowicz H., et al. The Food-Specific Serum IgG Reactivity in Major Depressive Disorder Patients, Irritable Bowel Syndrome Patients and Healthy Controls. Nutrients 2018, 10(5), 548. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986428/
  6. Simeonova D, et al. Recognizing the Leaky Guy as a Trans-diagnostic Target for Neuroimmune Disorders Using Clinical Chemistry and Molecular Immunology Assays. Curr Top Med Chem. 2018;18(19):1641-1655. Retrieved from: http://www.eurekaselect.com/167390/article
  7. Xiao N., et al. Food-specific IgGs Are Highly Increased in the Sera of Patients with Inflammatory Bowel Disease and Are Clinically Relevant to the Pathogenesis. Intern Med. 2018 Oct 1;57(19):2787-2798. doi: 10.2169/internalmedicine.9377-17. Epub 2018 May 18. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207831/
  8. Karakula-Juchnowicz H., et al. The role of IgG hypersensitivity in the pathogenesis and therapy of depressive disorders. Nutr Neurosci. 2017 Feb;20(2):110-118. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/25268936
  9. Kwiatkowski L., et al. Resolution of Allergic Rhinitis and Reactive Bronchospasm With Supplements and Food-specific Immunoglobulin G Elimination: A Case Report. Altern Ther Health Med.2016 Oct;22(S3):24-28. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/27866183
  10. Shakoor Z, et. al. Prevalence of IgG-mediated food intolerance among patients with allergic symptoms. Ann Saudi Med. 2016;36(6):386-390. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/27920409
  11. Clarke, DP, et.al. The relevance of using the C3d/immunoglobulin G test in clinical intervention. Altern Ther Health Med. 2015 Jan-Feb;21(1):16-27. https://www.ncbi.nlm.nih.gov/pubmed/25599429
  12. Virdee K, Musset J, Baral M, Cronin C, Langland J. Food-specific IgG Antibody-guided Elimination Diets Followed by Resolution of Asthma Symptoms and Reduction in Pharmacological Interventions in Two Patients: A Case Report. Glob Adv Health Med. 2015;4(1):62-6. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311561/
  13. Cai C, et al. Serologic Investigation of Food Specific Immunoglobulin G Antibodies in Patients with Inflammatory Bowel Diseases. PLOS November 2014: Volume 9; Issue 11, e112154. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/25393003
  14. Caio G, et al. Effect of gluten free diet on immune response to gliadin in patients with non-celiac gluten sensitivity. BMC Gastroenterol. 2014 Feb 13;14:26. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926852/
  15. Avdiniar E, et al. IgG-based elimination diet in migraine plus irritable bowel syndrome. Headache. 2013 Mar;53(3):514-25. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/23216231
  16. Alpay K, et al. Diet restriction in migraine, based on IgG against foods: A clinical double-blind, randomised, cross-over trial. Sage Journals (2010). Volume: 30 issue: 7, page(s): 829-837. Retrieved from: http://journals.sagepub.com/doi/abs/10.1177/0333102410361404
  17. Bentz S, et. al. Clinical relevance of IgG antibodies against food antigens in Crohn's disease: a double-blind cross-over diet intervention study. Digestion 2010; 81: 252–264. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/20130407
  18. Hodsdon W. ND and Heather Zwickey, PhD, (2010). Reproducibility and Reliability of Two Food Allergy Testing Methods. Natural Medicine Journal 2(3), March, 2010. Retrieved from: https://www.researchgate.net/publication/242659400_NMJ_Original_Research_R eproducibility_and_Reliability_of_Two_Food_Allergy_Testing_Methods
  19. Volpi N. and Maccari F. Serum IgG responses to food antigens in the Italian population evaluated by highly sensitive and specific ELISA test. J Immunoassay Immunochem. 2009;30(1):51-59. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/19117202
  20. Arroyave Hernandez CM, et al. Food allergy mediated by IgG antibodies associated with migraine in adults. Rev Alerg Mex. 2007 Sep-Oct;54(5):162-8. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/18693538
  21. Whorwell PJ. The growing case for an immunological component to irritable bowel syndrome. Clin and Exp Allergy. 2007;37:805-807. Retrieved from: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2222.2007.02736.x
  22. Yang C. M. and Y. Q. Li (2007). “[The therapeutic effects of eliminating allergic foods according to food-specific IgG antibodies in irritable bowel syndrome].” Zhonghua nei ke za zhi [Chinese journal of internal medicine] 46(8): 641-643. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/17967233
  23. Drisko J., B. Bischoff, et al. (2006). “Treating irritable bowel syndrome with a food elimination diet followed by food challenge and probiotics.” Journal of the American College of Nutrition 25(6): 514-522. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/17229899
  24. Zar S., et al. Food-specific IgG4 antibody-guided exclusion diet improves symptoms and rectal compliance in irritable bowel syndrome. Scand J Gastroenterol. 2005 Jul;40(7):800-7. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/16109655
  25. Zar S., et al. Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome. Am J Gastroenterol. 2005 Jul;100(7):1550-7. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/15984980
  26. Atkinson W., T. A. Sheldon, et al. (2004). “Food elimination based on IgG antibodies in irritable bowel syndrome: a randomized controlled trial.” Gut 53(10): 1459-1464. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/15361495
  27. Zar S., et al. Role of food hypersensitivity in irritable bowel syndrome. Minerva Med. 2002 Oct;93(5):403-12. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/12410172
  28. Zar S., et al. Food hypersensitivity and irritable bowel syndrome. Aliment Pharmacol Ther. 2001 Apr;15(4):439-49. Retrieved from: https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2036.2001.00951.x?sid=nlm%3Apubmed
  29. Dixon HS. Treatment of delayed food allergy based on specific immunoglobulin G RAST testing. Otolaryngol Head Neck Surg.2000;123:48-54. Retrieved from: https://www.ncbi.nlm.nih.gov/m/pubmed/10889481/
  30. Carini C., et al. Immune complexes in food-induced arthralgia. Ann Allergy.1987 Dec;59(6):422-8. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/3425981

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